Melatonin

Prescription-only medicine · Travel · UK online pharmacy

Melatonin, also sold under the brand name Circadin, is a prescription medication designed to treat short-term sleep issues, including insomnia and jet lag. Available in 2mg and 3mg tablets, it is a synthetic version of the natural hormone melatonin, helps regulate the body’s sleep-wake cycle.

Key facts

• Classification: Prescription-only medicine (POM) in the UK
• Treatment category: Travel
• Price (if prescribed): from £31.99
• Typical supply: 28 days
• Availability: Available following an online consultation
• Prescriber review: every order is assessed by a GPhC-registered pharmacist

Melatonin prices by dose and pack size

Prices correct as of 2026-08-21. The exact dose is confirmed during the clinical assessment.

Melatonin (Circadin): A Natural Sleep Aid for Insomnia and Jet Lag

What is Melatonin (Circadin)?

Melatonin, also sold under the brand name Circadin, is a prescription medication designed to treat short-term sleep issues, including insomnia and jet lag. Available in 2mg and 3mg tablets, it is a synthetic version of the natural hormone melatonin, helps regulate the body’s sleep-wake cycle.

At Medihealth Direct, Melatonin is available for the treatment of primary insomnia and jet lag, offering a natural and safer alternative to traditional sleeping pills.

What is Melatonin Used For?

Melatonin tablets are primarily used for:

1. Primary Insomnia
   • Improves sleep quality.
   • Reduces daytime sleepiness caused by lack of sleep.
2. Jet Lag
   • Adjusts the sleep-wake cycle to match new time zones during travel.

Melatonin is most effective for older adults with naturally lower levels of melatonin. It is also prescribed off-label for adults under 55 for insomnia.

How Does Melatonin Work?

Melatonin is a hormone that plays a critical role in the body’s circadian rhythm, also known as the sleep-wake cycle.

• When it gets dark, the brain’s pineal gland produces melatonin, signalling the body to sleep.
• In the morning, light suppresses melatonin production, promoting alertness.

By supplementing natural melatonin levels, this medication helps regulate sleep patterns, making it easier to fall asleep and stay asleep.

Benefits of Melatonin Tablets

• Improved Sleep: Helps increase total sleep time and reduces the time it takes to fall asleep.
• Natural Aid: Mimics the body’s natural hormone, with a lower risk of severe drowsiness or addiction compared to traditional sleeping aids.
• Safe for Short-Term Use: Effective for conditions like jet lag and short-term insomnia.

How to Take Melatonin

For Insomnia

• Take one 2mg modified-release tablet 1-2 hours before bedtime.
• Maximum treatment duration is 13 weeks.
• If no improvement occurs, consult your healthcare professional for alternative treatments.

For Jet Lag

• Take one 3mg immediate-release tablet 1-2 hours before bedtime at your destination.
• Do not exceed 6mg daily, and limit use to 5 days.
• Avoid taking tablets before 8 pm or after 4 am.

Missed Dose:

If you forget a dose but it is still nighttime, take it as soon as possible. Do not double up on doses to compensate.

Possible Side Effects

Melatonin is well-tolerated, with most side effects being mild and temporary.

Common Side Effects

• Headaches.
• Joint pain (arthralgia).
• Nausea or stomach discomfort.
• Mild drowsiness or fatigue.

Serious Side Effects (Rare):

• Allergic reactions (e.g., swelling of the face, lips, or throat).
• Chest pain.

If you experience persistent or severe side effects, contact your healthcare professional immediately.

Precautions When Taking Melatonin

• Pregnancy and Breastfeeding: Consult your healthcare professional before use.
• Autoimmune Diseases: Avoid use unless prescribed.
• Smoking: This may reduce the effectiveness of melatonin.
• Operating Machinery: As melatonin can cause drowsiness, avoid driving or using heavy machinery after taking it.
• Lifestyle Adjustments:
  • Avoid caffeine and heavy meals before bedtime.
  • Create a quiet, dark, and comfortable sleeping environment.

Drug Interactions

Melatonin may interact with certain medications, potentially altering its effectiveness. Inform your healthcare professional if you are taking:

• Antidepressants (e.g., fluvoxamine).
• Hormonal contraceptives or HRT.
• Epilepsy medications.
• NSAIDs (e.g., ibuprofen).
• Antibiotics.
• Medications for blood pressure or drug addiction.

For a full list, refer to the patient leaflet included with the medication.

How to Buy Melatonin Online Safely

You can purchase Melatonin at Medihealth Direct following a simple online consultation.

1. Consultation: Complete a quick medical questionnaire.
2. Healthcare Professional Review: Our UK-registered healthcare professional will assess your suitability.
3. Fast Delivery: Receive your medication with next-day delivery in discreet packaging.

Melatonin is prescription-only and not available over the counter in the UK.

Melatonin FAQs

Is Melatonin addictive?

No, Melatonin is non-addictive, making it safer than traditional sleeping aids.

How long does Melatonin stay in the body?

Melatonin typically stays in the body for 4-5 hours, but this can vary based on age and dosage.

Can I take Melatonin long-term?

Long-term effects are not well studied. Use Melatonin only as directed by your healthcare professional.

Can I overdose on Melatonin?

Overdosing is unlikely but may cause drowsiness, nausea, or headaches. Always stick to the prescribed dose.

Is Melatonin safe to buy online?

Yes, when purchased from reputable providers like Medihealth Direct, Melatonin is safe and regulated.

How does the online consultation for Melatonin work?

1. Complete a confidential online health questionnaire.
2. A GPhC-registered pharmacist reviews your answers and confirms whether the treatment is clinically appropriate.
3. If approved, your medication is dispensed by the pharmacy and delivered in discreet packaging by tracked UK delivery.

See how the service works or browse all treatments.