Orlistat

Prescription-only medicine · Weight loss · UK online pharmacy

Orlistat, also known under the brand name Xenical, is a clinically proven weight loss medication designed for individuals with a BMI over 30 or those with a BMI over 28 and weight-related health conditions. It works by preventing up to 30% of dietary fat from being absorbed into the body, supporting effective and sustainable weight loss when combined with a healthy lifestyle.

Key facts

• Classification: Prescription-only medicine (POM) in the UK
• Treatment category: Weight loss
• Price (if prescribed): from £26.24
• Typical supply: 28 days
• Availability: Available following an online consultation
• Prescriber review: every order is assessed by a GPhC-registered pharmacist

Orlistat prices by dose and pack size

Prices correct as of 2026-08-21. The exact dose is confirmed during the clinical assessment.

Orlistat (Xenical): Effective Prescription Weight Loss Medication

What is Orlistat (Xenical)?

Orlistat, also known under the brand name Xenical, is a clinically proven weight loss medication designed for individuals with a BMI over 30 or those with a BMI over 28 and weight-related health conditions. It works by preventing up to 30% of dietary fat from being absorbed into the body, supporting effective and sustainable weight loss when combined with a healthy lifestyle.

Orlistat vs Xenical vs Alli: What’s the Difference?

• Orlistat: The generic version, available as prescription-only in 120mg capsules.
• Xenical: The branded version of Orlistat, containing the same active ingredient and dosage.
• Alli: A lower-strength (60mg) over-the-counter alternative, preventing 25% of fat absorption, compared to 30% with Xenical.

How Does Orlistat Work?

Orlistat targets the enzymes in your digestive system that break down fat. By inhibiting these enzymes, the treatment prevents fat absorption in the intestines. Instead, undigested fat is passed through the body naturally.

This approach directly reduces calorie intake, helping you achieve steady and controlled weight loss.

How Long Does Orlistat Take to Work?

When paired with a balanced diet and regular exercise, noticeable weight loss can occur within 2–3 months. However, if after 12 weeks you have not lost at least 5% of your initial body weight, you should consult your healthcare professional about discontinuing treatment.

How to Maximise Results with Orlistat

1. Adopt a Low-Fat Diet: Aim for meals with no more than 30% fat content.
2. Exercise Regularly: Incorporate physical activity into your routine to enhance fat-burning.
3. Stay Consistent: Take Orlistat as directed, with meals or up to 1 hour after eating.
4. Plan Long-Term: Combine Orlistat with lifestyle changes for sustainable weight loss and maintenance.

How to Take Orlistat

• Take 1 capsule (120mg) with a meal containing fat, up to three times daily.
• Use a full glass of water to swallow the capsule.
• If you skip a meal or consume a fat-free meal, you can skip that dose.
• Always follow your healthcare professional’s guidance and the instructions in the patient leaflet.

Side Effects of Orlistat

Common side effects are primarily related to its fat-blocking mechanism and include:

• Increased bowel movements.
• Oily or fatty stools.
• Flatulence (with an oily discharge).
• Abdominal pain.

These side effects are typically mild and subside as your body adjusts. Consult a healthcare professional if side effects persist or worsen.

Who Can Use Orlistat?

Orlistat is suitable for individuals:

• With a BMI over 30.
• With a BMI over 28 and related conditions like type 2 diabetes or high blood pressure.

Who Should Avoid Orlistat?

Consult your healthcare professional if you:

• Are pregnant or breastfeeding.
• Have chronic malabsorption syndrome.
• Have liver or gallbladder issues.
• Are taking medications that may interact with Orlistat.

Benefits of Orlistat

1. Clinically Proven: Participants in trials experienced weight loss of 5–10% during treatment cycles.
2. Reduces Fat Absorption: Prevents up to 30% of dietary fat from being stored in the body.
3. Supports Overall Health: This may help lower cholesterol levels and improve BMI.
4. Works Alongside Diet and Exercise: Enhances the effectiveness of a healthy lifestyle.

Can You Buy Orlistat Online?

Yes, you can purchase Orlistat (Xenical) online from Medihealth Direct. You’ll need to complete a short online consultation reviewed by a licensed healthcare professional. Once approved, your prescription will be fulfilled and dispatched via next-day delivery in discreet packaging.

Orlistat FAQs

How Does Orlistat Work?

Orlistat blocks enzymes in the gut from digesting fat, reducing the amount absorbed into your body.

Does Orlistat Burn Existing Fat?

No, it only prevents dietary fat from being absorbed. Weight loss occurs as your body burns stored fat for energy.

How Long Should I Take Orlistat?

You can take Orlistat as long as you need to reach a healthy BMI. If you do not lose at least 5% of your weight in 12 weeks, treatment should be reviewed.

Can I Take Orlistat Without Eating?

No, Orlistat works only when dietary fat is present in your meal. Skip the dose if you skip a meal.

Is Orlistat Safe for Breastfeeding Women?

No, Orlistat is not recommended for breastfeeding women as it may affect nutrient absorption.

Can Orlistat Cause Hair Loss?

Hair loss is a rare side effect. Consult your healthcare professional if you experience sudden or severe hair loss.

Is It Safe to Buy Orlistat Online?

Yes, purchasing Orlistat from Medihealth Direct is safe. We follow strict UK medical guidelines and ensure all treatments are genuine.

What Happens if I Take Too Much Orlistat?

Taking more than the recommended dose increases the risk of side effects without improving weight loss. Contact a healthcare provider if you believe you’ve taken too much.

How does the online consultation for Orlistat work?

1. Complete a confidential online health questionnaire.
2. A GPhC-registered pharmacist reviews your answers and confirms whether the treatment is clinically appropriate.
3. If approved, your medication is dispensed by the pharmacy and delivered in discreet packaging by tracked UK delivery.

See how the service works or browse all treatments.