Weight loss
Support for every stage of treatment
Practical help with common side effects, and clear advice on when to get help.
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Nausea
Nausea often flares for a few days after a dose increase and settles as your gut adapts. Eating habits, a dose review with your prescriber and, if they judge it appropriate, other treatment are all options.
Try this first
- 1Serve smaller portions than feel normal, eat slowly and stop at no longer hungry rather than full.
- 2Keep fat modest. Fried food, pastry, cream and heavy cheese are the most reliable triggers in the first weeks.
- 3Sip fluids between meals rather than with food, and stay upright for an hour after eating.
Source: our guide GLP-1 side effects: managing nausea week by week
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Get help now if
- Severe, constant abdominal pain, especially pain going through to the back with repeated vomiting.
- Pain under the right ribs with fever or yellowing of the skin.
- You keep vomiting and cannot keep fluids down: call NHS 111 now.
For urgent advice contact NHS 111. In an emergency, call 999. You can report a suspected side effect through the Yellow Card scheme.
Constipation
Bowel changes can appear after a dose step. Our pharmacists can talk you through options in a secure message.
Try this first
- 1Increase fibre gradually through a balanced diet, rather than making a sudden large change.
- 2Drink water regularly and try a daily walk if you are able.
- 3Allow time for the toilet, do not put off the urge to go, and try resting your feet on a low stool.
Source: our guide NHS: constipation
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Products that can help
General sale
Fybogel Orange, 30 sachets
£9.49
Up to 1 per order
General sale
Movicol Ease, 20 sticks
£9.60
Up to 1 per order
General sale
Fybogel Plain, 30 sachets
£9.49
Up to 1 per order
General sale
Fybogel Lemon, 30 sachets
£9.49
Up to 1 per order
These go in your shop basket. If a treatment order is waiting to be paid, they're added to it at that checkout; otherwise they're paid and delivered separately.
Get help now if
- Blood in your poo, a sudden change in bowel habits or constipation that is not improving needs a GP review.
- Sudden severe tummy pain or vomiting blood needs emergency help: call 999 or go to A&E.
For urgent advice contact NHS 111. In an emergency, call 999. You can report a suspected side effect through the Yellow Card scheme.
Diarrhoea
Diarrhoea may occur during treatment, but do not assume every episode is a medicine side effect. Tell your prescriber about persistent or troublesome symptoms.
Try this first
- 1Drink fluids regularly, using small sips if you feel sick, to help prevent dehydration.
- 2Eat when you feel able; fatty or spicy meals may be harder to tolerate.
- 3Avoid fruit juice and fizzy drinks, which can make diarrhoea worse.
Source: our guide NHS: diarrhoea and vomiting
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Products that can help
General sale
Imodium Instants, 6 tablets
£4.39
Up to 1 per order
General sale
Imodium Original, 6 capsules
£3.35
Up to 1 per order
These go in your shop basket. If a treatment order is waiting to be paid, they're added to it at that checkout; otherwise they're paid and delivered separately.
Get help now if
- Bloody diarrhoea, persistent dehydration after rehydration sachets, or vomiting that prevents drinking: call NHS 111 now.
- Diarrhoea lasting more than seven days or vomiting for more than two days: call NHS 111.
- Sudden severe tummy pain, green vomit or vomiting blood: call 999 or go to A&E.
For urgent advice contact NHS 111. In an emergency, call 999. You can report a suspected side effect through the Yellow Card scheme.
Heartburn and reflux
Reflux can follow a dose step. Meal size, timing and how you sleep make a real difference.
Try this first
- 1Stop before uncomfortably full. A stretched stomach puts the most pressure on the valve.
- 2Leave three hours between your last food and lying down.
- 3Raise the head of the bed 10 to 15 cm with blocks or a wedge, rather than extra pillows.
Source: our guide Acid reflux over the festive season
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Products that can help
General sale
Pyrocalm Control 20mg, 14 tablets
£10.99
Up to 1 per order
General sale
Nexium Control, 14 tablets
£7.99
Up to 1 per order
General sale
Gaviscon Double Action mint, 48 tablets
£8.49
Up to 1 per order
These go in your shop basket. If a treatment order is waiting to be paid, they're added to it at that checkout; otherwise they're paid and delivered separately.
Get help now if
- Food sticking or pain on swallowing.
- Vomiting blood, passing black stools, or persistent vomiting.
- Crushing central chest pain on exertion or spreading to the arm or jaw: call 999.
For urgent advice contact NHS 111. In an emergency, call 999. You can report a suspected side effect through the Yellow Card scheme.
Hydration and nutrition
Food first. Smaller, regular meals and steady fluids matter more than any supplement.
Try this first
- 1On a bad day eat small, bland amounts regularly, such as crackers, toast or banana, rather than skipping food.
- 2If you are vomiting, prioritise fluids in small, frequent sips.
- 3Go easy on alcohol. It irritates the stomach and reliably worsens next-day queasiness.
Source: our guide GLP-1 side effects: managing nausea week by week
Products that can help
General sale
Dioralyte, 20 sachets
£15.99
Up to 1 per order
These go in your shop basket. If a treatment order is waiting to be paid, they're added to it at that checkout; otherwise they're paid and delivered separately.
Get help now if
- You keep vomiting and cannot keep fluids down: call NHS 111 now.
For urgent advice contact NHS 111. In an emergency, call 999. You can report a suspected side effect through the Yellow Card scheme.
Injection and storage tips
Missed doses and changing your injection day both have clear rules. Never inject twice to catch up.
Try this first
- 1If you miss a dose, check the window in your patient leaflet or the titration guide before taking it. Never take two doses to catch up.
- 2You can move your injection day for convenience, keeping the minimum gap between doses described in the guide.
- 3After more than two missed weeks, ask before restarting. Your prescriber may restart you at a lower step.
Source: our guide Dose titration explained
Get help now if
If you are worried about a symptom, contact NHS 111. In an emergency, call 999. You can report a suspected side effect through the Yellow Card scheme.
More than medicine
Food first, with people to talk to. Multivitamins are optional, not something everyone needs.
Health Coach
Habit and routine support alongside your treatment.
Nutritionist
Food-first guidance for smaller, regular meals.
Personal training
Sessions with a trainer.
Paid extraMonthly check-ins
Tell us how you are getting on before each delivery.
Ask Maya
Quick answers in chat, with a pharmacist a message away.
Frequently asked questions
Does more nausea mean the treatment is working better?
No. Plenty of people lose weight steadily with no sickness at all. Severe nausea mostly predicts an unpleasant month, not faster results.
Will side effects come back at every dose increase?
Each step is usually a little easier than the last. If one step is consistently rough, a longer pause at the lower dose is the usual answer.
Can my prescriber slow down my dose increases?
Yes. Holding the current dose for another month, dropping back one level or slowing the whole schedule are standard responses and do not undo your progress.
Can I add support items to my treatment order here?
Yes, while a weight-loss order is waiting for payment. General-sale items join it from this page or from your shop basket. Pharmacy and prescription items join after a short quick check that a pharmacist reviews before dispatch; you are only charged for items that are approved. On a monthly plan, choose items for your next delivery from your plan page.
Can vomiting or diarrhoea affect my contraceptive pill?
Vomiting or severe diarrhoea can affect pill protection. Follow the advice in your pill leaflet and ask a pharmacist or sexual health service about extra contraception and whether emergency contraception is needed. With tirzepatide, use a barrier method such as condoms as well as the pill for four weeks after starting and for four weeks after each dose increase, or discuss switching to a non-oral method.
Clinically reviewed
The advice here draws on our health guides and the NHS and MHRA sources listed below.
Sources
Items go to your shop basket and join your treatment order at checkout if one is waiting to be paid.